This research vector aims at developing ways for the local delivery of bioactive agents, to induce tissue regeneration or a certain therapeutic effect, by using adequate carriers, which can, in some cases, simultaneously act as scaffolds for adherence of relevant cell types.

The approach for deleniate the best controlled release strategy with the following steps:

• Sythesis and processing of natural original systhetic materials into scoffolds, micro and nanoparticles and stimuli-responsive materials (so-called smart materials);
• Development of different loading methods, such as surface adsorption, encapsulation (the bioactive agent is contained within a capsule of the material) or entrappement within the matrix of the system;
• Evaluation of the amount of loading of the bioactive agents and its release profile in static conditions;
• Modification of surface properties of the carriers, by changing the chemical properties, by the coating of the surface to control release of the loaded agents;
• The encapsulation of cells producing these above named bioactive agents, namely BMPs or other Growth and Differentiation factors.