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WP.3 Rapid-prototyping technique for scaffolds design and processing

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This research vector involves processing the materials into adequate parts and porous scaffolds, using innovative and non-conventional techniques, such as rapid-prototyping, in particular for applications demanding high control over the scaffold morphology. A significant challenge lies in designing the complex patient-specific scaffold geometries necessary for reconstructive tissue engineering applications. The idea is to use patient's own CT or MRI images to design a geometry that fits precisely into the place

  • Where repair and regeneration are needed.

It is also clear that research is necessary to:
  • To process materials into adequate parts and porous scaffolds, using innovative and non-conventional techniques, such as for instances rapid-prototyping;
  • To maximize its mechanical properties;
  • Evaluate to what extent the internal architecture of the scaffold is required to mimic (or should be based on) the architecture present in similar healthy tissues.
  • Define and apply an optimal internal architecture to the previously designed external geometry obtaining a virtual model of the custom scaffold and convert this data to a rapid prototyping (RP) machine to produce the scaffold. Develop computer methodologies to design customized scaffolds with external shapes that fit the patient defect and on which the interior architecture resembles or mimics the real tissue.

 
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